| Formulary Chapter 5: Infections - Full Chapter
|
|
| Chapter Links... |
 NICE NG199: Clostridioides difficile infection: antimicrobial prescribing |
| NICE NG15: Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use |
| NICE NG79: Sinusitis (acute): antimicrobial prescribing |
| NICE NG79: Sinusitis (acute): antimicrobial prescribing (visual summary) |
 Summary of antimicrobial prescribing guidance - managing common infections |
| Details... |
| 05.01 |
Antibacterial drugs |
|
|
Aminosalicylic Acid
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Tedizolid (Oral and IV )
|
Formulary
|
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|
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Telavancin
(Injectable)
|
Formulary
|
|
|
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Aminosalicylic Acid (Granupas 4 g gastro-resistant granules)
|
Formulary
|
Hospital use only under microbiological advice
|
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|
| 05.01.01 |
Penicillins |
|
|
| 05.01.01.01 |
Benzylpenicillin and phenoxymethylpenicillin |
|
|
Benzylpenicillin Benzathine
|
Formulary
|
For use by GUM & STD services only
|
|
|
Benzylpenicillin Sodium
|
Formulary
|
 Injectable for suspected Meningitis in Primary Care
In secondary care for related indications
|
UKMI Q&A: How do you treat syphilis with parenteral benylpenicillin?
|
Phenoxymethylpenicillin
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Procaine Penicillin G
(Injection)
|
Formulary
|
for hospital use only as advised by GUM
|
|
|
| 05.01.01.02 |
Penicillinase-resistant penicillins |
|
|
Flucloxacillin
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
|
Flucloxacillin
(Injection)
|
Formulary
|
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|
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Temocillin
(injection)
|
Formulary
|
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Temocillin (Negaban®)
|
Formulary
|
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|
|
| 05.01.01.03 |
Broad-spectrum penicillins |
|
|
Amoxicillin
(Injection)
|
Formulary
|
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|
|
Amoxicillin
(Oral presentations)
|
Formulary
|
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|
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Co-amoxiclav
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Co-amoxiclav
(Injection)
|
Formulary
|
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|
|
| 05.01.01.04 |
Antipseudomonal penicillins |
|
|
Piperacillin and Tazobactam
(injection)
|
Formulary
|
For hospital use only
|
|
|
| 05.01.01.05 |
Mecillinams |
|
|
Pivmecillinam Hydrochloride
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
|
| 05.01.02 |
Cephalosporins, carbapenems and other beta-lactums |
|
|
| 05.01.02 |
Other beta-lactam antibiotics |
|
|
| 05.01.02.01 |
Cephalosporins |
|
|
Cefalexin
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Cefotaxime
(Injection)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Cefazolin
|
Formulary
|
Hospital use only under microbiological advice
|
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|
Cefepime
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Cefiderocol (Fetcroja®)
|
Formulary
|
Hospital use only under microbiological advice. Blueteq applications required
|
|
|
Cefixime (Suprax®)
|
Formulary
|
Hospital use only under microbiological advice
|
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|
Ceftazidime
|
Formulary
|
Hospital use only under microbiological advice
Under OPAT sheme
|
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Ceftazidime with avibactam
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Ceftobiprole (Zevtera®)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Ceftolozane with tazobactam
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Ceftriaxone
|
 Restricted
|
Injectable - Green under OPAT scheme in Primary Care
Secondary care - for specific indications
|
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Cefuroxime (Oral and IV )
|
Formulary
|
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|
| 05.01.02.02 |
Carbapenems |
|
|
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Ertapenem
(injection)
|
Formulary
|
Amber Rec under OPAT Scheme in Primary care
Hospital use under microbiological advice
|
|
|
Imipenem with Cilastatin
(Infusion)
|
Formulary
|
For hospital use only
|
|
|
Imipenem with Cilastatin (Primaxin®)
(Infusion)
|
Formulary
|
For hospital use only
|
|
|
Imipenem with cilastatin and relebactam (Recarbrio®)
|
Formulary
|
|
|
|
Meropenem
(injection)
|
Formulary
|
Primary care-Amber Rec under agreed OPAT Pathway
Secondary care-Microbiological advice
|
|
|
Meropenem with vaborbactam (Vaborem® )
(IV)
|
Formulary
|
|
|
|
| 05.01.02.03 |
Other beta-lactums antibiotics |
|
|
Aztreonam
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
| 05.01.03 |
Tetracyclines |
|
|
Demeclocycline
(Capsules)
|
Formulary
|
For Antimicrobial use by Microbiologist and Hyponatraemia indications
|
|
|
Doxycycline
(Oral presentation)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
|
Lymecycline (oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Oxytetracycline (oral)
|
Formulary
|
Recommended by Dermatologist
|
|
|
Tetracycline
|
Formulary
|
Specialist Advice for H. pylori relapse only
|
Summary of antimicrobial prescribing guidance – managing common infections
|
| 05.01.03 |
Tigecycline |
|
|
Tigecycline
(Injection)
|
Formulary
|
|
|
|
| 05.01.04 |
Aminoglycosides |
|
|
Amikacin
(injection)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Amikacin (Amikin®)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Gentamicin
(injectable and IV)
|
Formulary
|
For hospital use only
|
|
|
|
Tobramycin (Munuza ®
|
Formulary
|
|
|
|
Tobramycin (Tymbrineb ® )
(Nebuliser)
|
Formulary
|
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|
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Tobramycin (Vantobra ® )
(Nebuliser)
|
Formulary
|
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|
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Tobramycin
(injection)
|
Formulary
|
|
|
|
Tobramycin (TOBI Podhaler®)
(Nebuliser solution)
|
Formulary
|
For specialist prescribing only
|
NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin (TA276)
|
Tobramycin (Bramitob®)
(Nebuliser)
|
Formulary
|
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Septopal
(30 bead chain)
|
Formulary
|
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| 05.01.05 |
Macrolides |
|
|
Azithromycin (Azyter®)
(15mg/g )
|
Formulary
|
|
|
|
Azithromycin
|
Formulary
|
Tablets/ suspension -For Sexual Health (GUM Clinics) in Primary care only
IV-For Respiratory Indications
|
Summary of antimicrobial Prescribing guidance-managing common infections
|
Clarithromycin
(injection)
|
Formulary
|
|
|
|
Clarithromycin
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Erythromycin
(tablets)
|
Formulary
|
|
Meds Q&A: Is there an interaction between erythromycin and statins?
Summary of antimicrobial prescribing guidance – managing common infections
|
Erythromycin ethyl succinate
(Oral suspension)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
|
Erythromycin lactobionate
(injection)
|
Formulary
|
|
|
|
| 05.01.06 |
Clindamycin |
|
|
Clindamycin
(Capsules)
|
Formulary
|
Use 150mg capsules
 300mg capsules are Non-formulary
|
|
|
Clindamycin (300mg/2ml)
(Injection)
|
Formulary
|
|
|
|
| 05.01.07 |
Some other antibacterials |
|
|
Nitazoxanide (Alinia®)
(Oral powder for reconstitution to suspension, Tablet)
|
Restricted
|
For Hospital Use Only
|
|
|
Bedaquiline
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Dalbavancin
|
Restricted
|
Hospital use only under microbiological advice
|
|
|
| 05.01.07 |
Chloramphenicol |
|
|
Chloramphenicol
(Oral and injection)
|
Formulary
|
For specialist use only
|
|
|
| 05.01.07 |
Fosfomycin |
|
|
| 05.01.07 |
Fusidic acid |
|
|
Fusidic acid
(Tablet, oral suspension)
|
Formulary
|
|
|
|
Sodium fusidate
(IV Infusion)
|
Formulary
|
|
|
|
Sodium fusidate
(Tablets)
|
Formulary
|
|
|
|
| 05.01.07 |
Vancomycin and teicoplanin |
|
|
Teicoplanin
(Oral ,IV and injection)
|
Formulary
|
For hospital use only
|
|
|
Vancomycin
(Capsules)
|
Formulary
|
|
|
|
Vancomycin
(Injection)
|
Formulary
|
|
|
|
| 05.01.07 |
Daptomycin |
|
|
Daptomycin
(injection)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
| 05.01.07 |
Linezolid |
|
|
Linezolid
(Oral formulations)
|
Formulary
|
For hospital use only
|
|
|
Linezolid
(infusion)
|
Formulary
|
For hospital use only
|
|
|
| 05.01.07 |
Quinupristin and dalfopristin |
|
|
| 05.01.07 |
Polymyxins |
|
|
Colistimethate
(Injection)
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Colistimethate (Promixin®)
|
Formulary
|
|
|
|
Colistimethate for nebulisation
|
Formulary
|
|
|
|
Colistimethate for nebulisation (Colomycin®)
|
Formulary
|
|
|
|
Colistimethate inhaler (Colobreathe®)
|
Formulary
|
|
|
|
| 05.01.07 |
Rifaximin |
|
|
Rifaximin (oral presentations)
|
Formulary
|
|
NICE TA 337 :Rifaximin for preventing episodes of overt hepatic encephalopathy
|
| 05.01.07 |
Fidaxomicin |
|
|
Fidaxomicin
(Tablets)
|
Formulary
|
On Microbiological advice only
|
|
|
| 05.01.08 |
Sulphonamides and trimethoprim |
|
|
Co-trimoxazole
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Co-trimoxazole
(IV Infusion)
|
Formulary
|
|
|
|
Trimethoprim
(IV)
|
Formulary
|
|
|
|
Trimethoprim
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
|
| 05.01.09 |
Antituberculosis drugs |
|
|
Rifampicin (Rimactane®)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Capreomycin
|
Formulary
|
Hospital use only under Microbiological/Tuberculosis advice only
|
NICE NG33: Tuberculosis
|
Cycloserine
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Delamanid (Deltyba ®)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Ethambutol
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
Ethambutol liquid 400mg in 5ml (unlicensed)
|
|
|
Isoniazid
(Oral ,IV and injection)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Prothionamide
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Pyrazinamide
|
Formulary
|
Pyrazinamide liquid 500mg in 5ml (unlicensed)
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifabutin
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifampicin
(Oral presentations)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifampicin
(infusion)
|
Formulary
|
|
|
|
Rifampicin and Isoniazid (Rifinah® 300)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifampicin and Isoniazid (Rifinah® 150)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifampicin and Isoniazid and Pyrazinamide (Rifater®)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Rifampicin, isoniazid, pyrazinamide and ethambutol (Voractiv®)
(Tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Streptomycin Sulphate
|
Formulary
|
|
|
|
Isoniazid
(solution SF)
|
 Unlicensed
|
Unlicensed special.
|
|
|
|
|
| 05.01.10 |
Antileprotic drugs |
|
|
Clofazimine
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
|
|
Dapsone
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Thalidomide (oral presentations)
|
Formulary
|
|
|
|
| 05.01.11 |
Metronidazole and tinidazole |
|
|
Metronidazole
|
Formulary
|
Tablets
Suspension £££££
|
Summary of antimicrobial prescribing guidance – managing common infections
UKMI Q&A: Metronidazole - is it safe to use with breastfeeding?
|
Metronidazole
(infusion)
|
Formulary
|
|
|
|
Metronidazole
(suppositories)
|
Formulary
|
|
|
|
| 05.01.12 |
Quinolones |
|
|
Ciprofloxacin
(Oral presentations, ear drops, eye drops and eye ointment)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Ciprofloxacin
(Infusion)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Levofloxacin
(Infusion)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Levofloxacin
(Tablets)
|
Formulary
|
- For multi resistant organisms, based on Microbiological sensitivity
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Moxifloxacin
(Oral,IV)
|
Formulary
|
Hospital use only under microbiological advice
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Norfloxacin
(Tablets)
|
Formulary
|
Hospital use only under microbiological advice
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Ofloxacin
(Oral,IV)
|
Formulary
|
Hospital use only under microbiological advice /GUM
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
| 05.01.13 |
Urinary-tract infections |
|
|
Fosfomycin
(Sachets, Capsules)
|
Formulary
|
Second line treatment for sensitivities
|
NICE CG97: Lower urinary tract symptoms in men: management
Summary of antimicrobial prescribing guidance – managing common infections
NICE CG54: Urinary tract infection in under 16s: diagnosis and management
|
Fosfomycin Injection
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Methenamine hippurate
(Tablets)
|
Formulary
|
- On Microbiology/Urology advice
- Prescribing to be retained by Secondary care
|
|
|
Nitrofurantoin
(Tablets, MR Capsules,suspension)
|
Formulary
|
Modified release capsules preferred formulation-First line
Oral Suspension £££££
|
Nitrofurantoin now contraindicated in most patients with an estimated glomerular filtration rate (eGFR) of less than 45 ml/min/1.73m2
Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
|
Trimethoprim
(Tablets)
|
Formulary
|
Second choice in UTI
|
Summary of antimicrobial prescribing guidance – managing common infections (January 2022)
Urinary tract infection information leaflet
|
|
|
|
|
|
|
| .... |
| Non Formulary Items |
Amikacin (Arikayce liposomal 590mg nebuliser dispersion)
|
Non Formulary
|
|
|
|
Ampicillin
|
Non Formulary
|
|
|
|
Ampicillin
|
Non Formulary
|
|
|
|
Azithromycin (Zedbac)
|
Non Formulary
|
|
|
|
Azithromycin (Zithromax)
|
Non Formulary
|
|
|
|
Aztreonam nebuliser solution (Cayston®)
|
Non Formulary
|
|
|
|
Cefaclor
|
Non Formulary
|
|
|
|
Cefaclor (Distaclor®)
|
Non Formulary
|
|
|
|
Cefaclor (Distaclor® MR)
|
Non Formulary
|
|
|
|
Cefadroxil
|
Non Formulary
|
|
|
|
Cefoxitin
|
Non Formulary
|
|
|
|
Cefoxitin (Renoxitin®)
|
Non Formulary
|
|
|
|
Cefpodoxime
|
Non Formulary
|
|
|
|
Cefradine
|
Non Formulary
|
|
|
|
Ceftaroline (Zinforo®)
|
Non Formulary
|
|
|
|
Cefuroxime Axetil
|
Non Formulary
|
|
|
|
Ciprofloxacin (Ciproxin®)
|
Non Formulary
|
|
|
|
Clarithromycin (Klaricid®)
|
Non Formulary
|
|
|
|
Clarithromycin (Klaricid® XL)
|
Non Formulary
|
|
|
|
Clarithromycin (Xetinin XL®)
|
Non Formulary
|
|
|
|
Clindamycin (Dalacin C®)
|
Non Formulary
|
|
|
|
Clindamycin 300mg Capsules
|
Non Formulary
|
|
|
|
Co-Amoxiclav (Augmentin®)
|
Non Formulary
|
|
|
|
Co-Amoxiclav (Augmentin-Duo®)
|
Non Formulary
|
|
|
|
Co-Fluampicil
|
Non Formulary
|
|
|
|
Collatamp EG Sponge
|
Non Formulary
|
|
|
|
Daptomycin (Cubicin®)
|
Non Formulary
|
|
|
|
Delafloxacin (Quofenix®)
|
Non Formulary
|
|
|
|
Ertapenem (Invanz®)
(injection)
|
Non Formulary
|
|
|
|
Erythromycin (Erythrocin®)
|
Non Formulary
|
|
|
|
Erythromycin (Erythroped®)
|
Non Formulary
|
|
|
|
Fidaxomicin (Dificlir®)
|
Non Formulary
|
|
|
|
Fosfomycin (Fomicyt ®)
|
Non Formulary
|
|
|
|
Fosfomycin 3g granules sachets (Alexi ®)
|
Non Formulary
|
|
|
|
Fosfomycin 3g granules sachets (Monuril ®)
|
Non Formulary
|
|
|
|
Levofloxacin 240mg nebuliser solution ampoules (Quinsair®)
|
Non Formulary
|
|
|
|
Linezolid (Zyvox®)
|
Non Formulary
|
|
|
|
Lymecycline (Tetralysal 300 capsules®)
|
Non Formulary
|
|
|
|
Minocycline
|
Non Formulary
|
|
|
|
Minocycline (Acnamino® MR)
|
Non Formulary
|
|
|
|
Minocycline (Minocin® MR)
|
Non Formulary
|
|
|
|
Neomycin sulphate
(tablets)
|
Non Formulary
|
For hospital use only or advice from Specialist/Microbiologist |
|
|
Nitrofurantoin (Macrobid®)
|
Non Formulary
|
|
|
|
Oritavancin
|
Non Formulary
|
|
|
|
Pivmecillinam (Selexid®)
|
Non Formulary
|
|
|
|
Quinupristin and dalfopristin (Synercid®)
(injection)
|
Non Formulary
|
|
|
|
Telithromycin (Ketek®)
|
Non Formulary
|
|
|
|
Tinidazole (Fasigyn®)
|
Non Formulary
|
|
|
|
| |
Key |
|
Restricted Drug |
|
Unlicensed |
|
|
Link to adult BNF
|
|
|
Link to children's BNF
|
|
|
Link to SPCs
|
|
Cytotoxic Drug |
|
Controlled Drug |
|
|
High Cost Medicine |
|
Cancer Drugs Fund |
|
NHS England |
|
Homecare |
|
ICB |
|
Low carbon footprint |
|
Medium carbon footprint |
|
High carbon footprint |
|
| Status |
Description |
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Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications |
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Amber Specialist Initiation: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate. This may be supported by a RICaD, annotated within the formulary entry. |
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Amber Shared Care: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing, in accordance with an ESCA, annotated within the formulary entry. |
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Amber Specialist Recommendation: Initiation and maintenance of prescribing in Primary Care following recommendation from a specialist. |
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Medicines for initiation and maintenance prescribing by Specialists (hospital or GPs with Special Interest) only |
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Positive NICE TA and /or awaiting local clarification on place in therapy; Please contact your Medicines Optimisation team for more information. |
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Non-formulary Medicines which APC/Trust DTC has actively reviewed and do not recommend for use. |
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Check Notes as varies across the area |
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