| Formulary Chapter 5: Infections - Full Chapter
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| Chapter Links... |
 NICE NG199: Clostridioides difficile infection: antimicrobial prescribing |
| NICE NG15: Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use |
| NICE NG79: Sinusitis (acute): antimicrobial prescribing |
| NICE NG79: Sinusitis (acute): antimicrobial prescribing (visual summary) |
 Summary of antimicrobial prescribing guidance - managing common infections |
| Details... |
| 05.01 |
Antibacterial drugs |
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Aminosalicylic Acid
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Formulary
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Hospital use only under microbiological advice
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Tedizolid (Oral and IV )
|
Formulary
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Telavancin
(Injectable)
|
Formulary
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Aminosalicylic Acid (Granupas 4 g gastro-resistant granules)
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Formulary
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Hospital use only under microbiological advice
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| 05.01.01 |
Penicillins |
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| 05.01.01.01 |
Benzylpenicillin and phenoxymethylpenicillin |
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Benzylpenicillin Benzathine
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Formulary
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For use by GUM & STD services only
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Benzylpenicillin Sodium
|
Formulary
|
 Injectable for suspected Meningitis in Primary Care
In secondary care for related indications
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UKMI Q&A: How do you treat syphilis with parenteral benylpenicillin?
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Phenoxymethylpenicillin
(Oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance - managing common infections
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Procaine Penicillin G
(Injection)
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Formulary
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for hospital use only as advised by GUM
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| 05.01.01.02 |
Penicillinase-resistant penicillins |
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Flucloxacillin
(Injection)
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Formulary
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Flucloxacillin
(Oral presentations)
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Formulary
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Summary of antimicrobial prescribing guidance – managing common infections
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Temocillin
(injection)
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Formulary
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Temocillin (Negaban®)
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Formulary
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| 05.01.01.03 |
Broad-spectrum penicillins |
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Amoxicillin
(Injection)
|
Formulary
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Amoxicillin
(Oral presentations)
|
Formulary
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Co-amoxiclav
(Oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance - managing common infections
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Co-amoxiclav
(Injection)
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Formulary
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| 05.01.01.04 |
Antipseudomonal penicillins |
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Piperacillin and Tazobactam
(injection)
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Formulary
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For hospital use only
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| 05.01.01.05 |
Mecillinams |
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Pivmecillinam Hydrochloride
(Oral presentations)
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Formulary
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Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
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| 05.01.02 |
Cephalosporins, carbapenems and other beta-lactums |
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| 05.01.02 |
Other beta-lactam antibiotics |
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| 05.01.02.01 |
Cephalosporins |
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Cefalexin
(Oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance - managing common infections
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Cefotaxime
(Injection)
|
Formulary
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Hospital use only under microbiological advice
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Cefazolin
|
Formulary
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Hospital use only under microbiological advice
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Cefepime
|
Formulary
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Hospital use only under microbiological advice
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Cefiderocol (Fetcroja®)
|
Formulary
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Hospital use only under microbiological advice. Blueteq applications required
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Cefixime (Suprax®)
|
Formulary
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Hospital use only under microbiological advice
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Ceftazidime
|
Formulary
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Hospital use only under microbiological advice
Under OPAT sheme
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Ceftazidime with avibactam
|
Formulary
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Hospital use only under microbiological advice
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Ceftobiprole (Zevtera®)
|
Formulary
|
Hospital use only under microbiological advice
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Ceftolozane with tazobactam
|
Formulary
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Hospital use only under microbiological advice
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Ceftriaxone
|
 Restricted
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Injectable - Green under OPAT scheme in Primary Care
Secondary care - for specific indications
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Cefuroxime (Oral and IV )
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Formulary
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| 05.01.02.02 |
Carbapenems |
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Ertapenem
(injection)
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Formulary
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Amber Rec under OPAT Scheme in Primary care
Hospital use under microbiological advice
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Imipenem with Cilastatin
(Infusion)
|
Formulary
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For hospital use only
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Imipenem with Cilastatin (Primaxin®)
(Infusion)
|
Formulary
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For hospital use only
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Imipenem with cilastatin and relebactam (Recarbrio®)
|
Formulary
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Meropenem
(injection)
|
Formulary
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Primary care-Amber Rec under agreed OPAT Pathway
Secondary care-Microbiological advice
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Meropenem with vaborbactam (Vaborem® )
(IV)
|
Formulary
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| 05.01.02.03 |
Other beta-lactums antibiotics |
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Aztreonam
|
Formulary
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Hospital use only under microbiological advice
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| 05.01.03 |
Tetracyclines |
|
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Demeclocycline
(Capsules)
|
Formulary
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For Antimicrobial use by Microbiologist and Hyponatraemia indications
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Doxycycline
(Oral presentation)
|
Formulary
|
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Summary of antimicrobial prescribing guidance – managing common infections
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Lymecycline (oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance - managing common infections
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Oxytetracycline (oral)
|
Formulary
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Recommended by Dermatologist
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Tetracycline
|
Formulary
|
Specialist Advice for H. pylori relapse only
|
Summary of antimicrobial prescribing guidance – managing common infections
|
| 05.01.03 |
Tigecycline |
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Tigecycline
(Injection)
|
Formulary
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| 05.01.04 |
Aminoglycosides |
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Amikacin
(injection)
|
Formulary
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Hospital use only under microbiological advice
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Amikacin (Amikin®)
|
Formulary
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Hospital use only under microbiological advice
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Gentamicin
(injectable and IV)
|
Formulary
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For hospital use only
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Tobramycin (Munuza ®
|
Formulary
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Tobramycin (Tymbrineb ® )
(Nebuliser)
|
Formulary
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Tobramycin (Vantobra ® )
(Nebuliser)
|
Formulary
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Tobramycin
(injection)
|
Formulary
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Tobramycin (TOBI Podhaler®)
(Nebuliser solution)
|
Formulary
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For specialist prescribing only
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NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin (TA276)
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Tobramycin (Bramitob®)
(Nebuliser)
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Formulary
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Septopal
(30 bead chain)
|
Formulary
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| 05.01.05 |
Macrolides |
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Azithromycin (Azyter®)
(15mg/g )
|
Formulary
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Azithromycin
|
Formulary
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Tablets/ suspension -For Sexual Health (GUM Clinics) in Primary care only
IV-For Respiratory Indications
|
Summary of antimicrobial Prescribing guidance-managing common infections
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Clarithromycin
(injection)
|
Formulary
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Clarithromycin
(Oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance - managing common infections
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Erythromycin
(tablets)
|
Formulary
|
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Meds Q&A: Is there an interaction between erythromycin and statins?
Summary of antimicrobial prescribing guidance – managing common infections
|
Erythromycin ethyl succinate
(Oral suspension)
|
Formulary
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Summary of antimicrobial prescribing guidance – managing common infections
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Erythromycin lactobionate
(injection)
|
Formulary
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| 05.01.06 |
Clindamycin |
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Clindamycin
(Capsules)
|
Formulary
|
Use 150mg capsules
 300mg capsules are Non-formulary
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Clindamycin (300mg/2ml)
(Injection)
|
Formulary
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| 05.01.07 |
Some other antibacterials |
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Nitazoxanide (Alinia®)
(Oral powder for reconstitution to suspension, Tablet)
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Restricted
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For Hospital Use Only
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Bedaquiline
|
Formulary
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Hospital use only under microbiological and Tuberculosis specialist advice
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Dalbavancin
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Restricted
|
Hospital use only under microbiological advice
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| 05.01.07 |
Chloramphenicol |
|
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Chloramphenicol
(Oral and injection)
|
Formulary
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For specialist use only
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| 05.01.07 |
Fosfomycin |
|
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| 05.01.07 |
Fusidic acid |
|
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Fusidic acid
(Tablet, oral suspension)
|
Formulary
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Sodium fusidate
(IV Infusion)
|
Formulary
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Sodium fusidate
(Tablets)
|
Formulary
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| 05.01.07 |
Vancomycin and teicoplanin |
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Teicoplanin
(Oral ,IV and injection)
|
Formulary
|
For hospital use only
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Vancomycin
(Capsules)
|
Formulary
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Vancomycin
(Injection)
|
Formulary
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| 05.01.07 |
Daptomycin |
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Daptomycin
(injection)
|
Formulary
|
Hospital use only under microbiological advice
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| 05.01.07 |
Linezolid |
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Linezolid
(Oral formulations)
|
Formulary
|
For hospital use only
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Linezolid
(infusion)
|
Formulary
|
For hospital use only
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| 05.01.07 |
Quinupristin and dalfopristin |
|
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| 05.01.07 |
Polymyxins |
|
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Colistimethate
(Injection)
|
Formulary
|
Hospital use only under microbiological advice
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Colistimethate (Promixin®)
|
Formulary
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Colistimethate for nebulisation
|
Formulary
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Colistimethate for nebulisation (Colomycin®)
|
Formulary
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Colistimethate inhaler (Colobreathe®)
|
Formulary
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| 05.01.07 |
Rifaximin |
|
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Rifaximin (oral presentations)
|
Formulary
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|
NICE TA 337 :Rifaximin for preventing episodes of overt hepatic encephalopathy
|
| 05.01.07 |
Fidaxomicin |
|
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Fidaxomicin
(Tablets)
|
Formulary
|
On Microbiological advice only
|
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| 05.01.08 |
Sulphonamides and trimethoprim |
|
|
Co-trimoxazole
(Oral presentations)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance - managing common infections
|
Co-trimoxazole
(IV Infusion)
|
Formulary
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Trimethoprim
(IV)
|
Formulary
|
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Trimethoprim
(Oral presentations)
|
Formulary
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Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
|
| 05.01.09 |
Antituberculosis drugs |
|
|
Rifampicin (Rimactane®)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
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Capreomycin
|
Formulary
|
Hospital use only under Microbiological/Tuberculosis advice only
|
NICE NG33: Tuberculosis
|
Cycloserine
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
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Delamanid (Deltyba ®)
|
Formulary
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Hospital use only under microbiological and Tuberculosis specialist advice
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Ethambutol
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
Ethambutol liquid 400mg in 5ml (unlicensed)
|
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Isoniazid
(Oral ,IV and injection)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Prothionamide
|
Formulary
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Hospital use only under microbiological and Tuberculosis specialist advice
|
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Pyrazinamide
|
Formulary
|
Pyrazinamide liquid 500mg in 5ml (unlicensed)
Hospital use only under microbiological and Tuberculosis specialist advice
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Rifabutin
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Rifampicin
(Oral presentations)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Rifampicin
(infusion)
|
Formulary
|
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Rifampicin and Isoniazid (Rifinah® 300)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Rifampicin and Isoniazid (Rifinah® 150)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Rifampicin and Isoniazid and Pyrazinamide (Rifater®)
(tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Rifampicin, isoniazid, pyrazinamide and ethambutol (Voractiv®)
(Tablets)
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Streptomycin Sulphate
|
Formulary
|
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Isoniazid
(solution SF)
|
 Unlicensed
|
Unlicensed special.
|
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| 05.01.10 |
Antileprotic drugs |
|
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Clofazimine
|
Formulary
|
Hospital use only under microbiological and Tuberculosis specialist advice
|
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Dapsone
|
Formulary
|
Hospital use only under microbiological advice
|
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Thalidomide (oral presentations)
|
Formulary
|
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| 05.01.11 |
Metronidazole and tinidazole |
|
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Metronidazole
(infusion)
|
Formulary
|
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Metronidazole
(suppositories)
|
Formulary
|
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Metronidazole
|
Formulary
|
Tablets
Suspension £££££
|
Summary of antimicrobial prescribing guidance – managing common infections
UKMI Q&A: Metronidazole - is it safe to use with breastfeeding?
|
| 05.01.12 |
Quinolones |
|
|
Ciprofloxacin
(Oral presentations, ear drops, eye drops and eye ointment)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Ciprofloxacin
(Infusion)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Levofloxacin
(Tablets)
|
Formulary
|
- For multi resistant organisms, based on Microbiological sensitivity
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Levofloxacin
(Infusion)
|
Formulary
|
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Moxifloxacin
(Oral,IV)
|
Formulary
|
Hospital use only under microbiological advice
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Norfloxacin
(Tablets)
|
Formulary
|
Hospital use only under microbiological advice
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
Ofloxacin
(Oral,IV)
|
Formulary
|
Hospital use only under microbiological advice /GUM
|
Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
|
| 05.01.13 |
Urinary-tract infections |
|
|
Fosfomycin
(Sachets, Capsules)
|
Formulary
|
Second line treatment for sensitivities
|
NICE CG97: Lower urinary tract symptoms in men: management
Summary of antimicrobial prescribing guidance – managing common infections
NICE CG54: Urinary tract infection in under 16s: diagnosis and management
|
Fosfomycin Injection
|
Formulary
|
Hospital use only under microbiological advice
|
|
|
Methenamine hippurate
(Tablets)
|
Formulary
|
- On Microbiology/Urology advice
- Prescribing to be retained by Secondary care
|
|
|
Nitrofurantoin
(Tablets, MR Capsules,suspension)
|
Formulary
|
Modified release capsules preferred formulation-First line
Oral Suspension £££££
|
Nitrofurantoin now contraindicated in most patients with an estimated glomerular filtration rate (eGFR) of less than 45 ml/min/1.73m2
Summary of antimicrobial prescribing guidance – managing common infections
Urinary tract infection information leaflet
|
Trimethoprim
(Tablets)
|
Formulary
|
Second choice in UTI
|
Summary of antimicrobial prescribing guidance – managing common infections (January 2022)
Urinary tract infection information leaflet
|
|
|
|
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|
|
| 05.02 |
Antifungal drugs |
|
|
Amphotericin
(Infusion)
|
Formulary
|
|
|
|
Amphotericin
(Lipid Complex Infusion)
|
Formulary
|
|
|
|
Amphotericin (AmBisome ®)
(IV Infusion)
|
Formulary
|
|
|
|
Amphotericin (Fungizone ®)
(IV Infusion)
|
Formulary
|
|
|
|
Flucytosine
|
Formulary
|
|
|
|
Nystatin
(Oral suspension)
|
Formulary
|
Not sugar Free
|
Summary of antimicrobial prescribing guidance – managing common infections
|
Terbinafine
(Tablets)
|
Formulary
|
|
Summary of antimicrobial prescribing guidance – managing common infections
|
| 05.02.01 |
Triazole antifungals |
|
|
Fluconazole
(Oral presentations)
|
Formulary
|
Capsules
Suspension - Only for patients with swallowing difficulties
|
Summary of antimicrobial prescribing guidance – managing common infections
UKMI Q&A: Can oral fluconazole be used with breastfeeding?
|
Fluconazole
(infusion)
|
Formulary
|
|
|
|
Isavuconazole
|
Formulary
|
|
|
|
Itraconazole
(Injection)
|
Formulary
|
|
|
|
Itraconazole (oral presentations)
|
Formulary
|
Capsules more cost effective
SF Liquid £££££
|
Summary of antimicrobial prescribing guidance – managing common infections
|
Posaconazole
|
Formulary
|
|
|
|
Voriconazole
|
Formulary
|
|
|
|
| 05.02.02 |
Imidazole antifungals |
|
|
Ketoconazole
(Oral)
|
Formulary
|
Specialist use only
|
MHRA alert: Risk of hepatotoxicity with oral ketoconazole
|
| 05.02.03 |
Polyene antifungals |
|
|
| 05.02.04 |
Echinocandin antifungals |
|
|
Anidulafungin
(IV)
|
Formulary
|
|
|
|
Caspofungin
(injection)
|
Formulary
|
|
|
|
Micafungin
(infusion)
|
Formulary
|
|
|
|
| 05.02.05 |
Other antifungals |
|
|
Flucytosine (Ancotil®)
(infusion)
|
Formulary
|
|
|
|
Griseofulvin
(Oral presentations)
|
Formulary
|
|
|
|
Sotrovimab
(IV)
|
Formulary
|
|
|
|
| 05.03 |
Antiviral drugs |
|
|
Molnupiravir
(Oral )
|
Formulary
|
|
|
|
Peginterferon Alfa
|
Formulary
|
Hospital only
In line with NICE
|
NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
|
Peginterferon Alfa (Pegasys®)
|
Formulary
|
Hospital only
In line with NICE
|
NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
|
Remdesivir (Veklury®)
(IV)
|
Formulary
|
|
|
|
| 05.03.01 |
HIV infection |
|
|
| 05.03.01 |
Nucleoside reverse transcriptase inhibitors |
|
|
Abacavir
(Tablets)
|
Formulary
|
|
|
|
Abacavir and Lamivudine
|
Formulary
|
|
|
|
Abacavir with dolutegravir and lamivudine (Triumeq ®)
(Tablets)
|
Formulary
|
|
|
|
Efavirenz with emtricitabine and tenofovir disoproxil
|
Formulary
|
|
|
|
Elvitegravir with cobicistat, emtricitabine and tenofovir alafenamide (Genvoya®)
|
Formulary
|
|
|
|
Emtricitabine (Emtriva®)
(Oral presentations)
|
Formulary
|
|
|
|
Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg (Eviplera®)
|
Formulary
|
Blueteq /prior approval form
|
|
|
Emtricitabine with rilpivirine and tenofovir alafenamide ( Odefsey® )
|
Formulary
|
|
|
|
Emtricitabine with tenofovir alafenamide (Descovy®)
|
Formulary
|
|
|
|
Emtricitabine with tenofovir disoproxil
|
Formulary
|
|
|
|
Lamivudine
|
Formulary
|
|
|
|
Lamivudine (Epivir®, Zeffix®)
|
Formulary
|
|
|
|
Lamivudine with dolutegravir (Dovato®)
(Oral )
|
Formulary
|
|
|
|
Lamivudine with tenofovir disoproxil and doravirine (Delstrigo®)
(Oral )
|
Formulary
|
|
|
|
Rilpivirine hydrochloride (Edurant®)
(tablets)
|
Formulary
|
|
|
|
Rilpivirine hydrochloride (Rekambys®)
(IV)
|
Formulary
|
|
|
|
Tenofovir, cobicistat, elvitegravir & emtricitabine (Stribild®)
|
Formulary
|
|
|
|
Zidovudine
(capsules )
|
Formulary
|
|
|
|
Zidovudine (Retrovir®)
(IV & SF solution)
|
Formulary
|
|
|
|
Zidovudine and Lamivudine
(tablets)
|
Formulary
|
|
|
|
| 05.03.01 |
Protease inhibitors |
|
|
Atazanavir
(capsules)
|
Formulary
|
|
|
|
Atazanavir with cobicistat (Evotaz®)
|
Formulary
|
Blueteq /prior approval form
|
|
|
Baloxavir marboxil
(Tablets)
|
Formulary
|
|
|
|
Bictegravir with emtricitabine and tenofovir alafenamide (Biktarvy®)
|
Formulary
|
|
|
|
Darunavir
|
Formulary
|
|
|
|
Darunavir with cobicistat (Rezolsta®)
|
Formulary
|
Blueteq /prior approval form
|
|
|
Darunavir with cobicistat, emtricitabine and tenofovir alafenamide (Symtuza®)
|
Formulary
|
Blueteq /prior approval form
|
|
|
Dolutegravir (Tivicay ®)
|
Formulary
|
|
|
|
Dolutegravir with rilpivirine (Juluca®)
|
Formulary
|
|
|
|
Fosamprenavir (Telzir®)
(tablets)
|
Formulary
|
|
|
|
Lopinavir and Ritonavir (Kaletra®)
(tablets & solution)
|
Formulary
|
|
|
|
Lopinavir with Ritonavir
(Oral )
|
Formulary
|
|
|
|
Nirmatrelvir With Ritonavir
|
Formulary
|
|
|
|
Ritonavir
(Oral presentations)
|
Formulary
|
|
|
|
| 05.03.01 |
Non-nucleoside reverse transcriptase inhibitors |
|
|
Doravirine (Pifeltro®)
|
Formulary
|
|
|
|
Etravirine (Intelence®)
(tablets)
|
Formulary
|
|
|
|
Nevirapine
|
Formulary
|
|
|
|
Nevirapine (Viramune®)
(tablets, extended release tablets & suspension)
|
Formulary
|
|
|
|
| 05.03.01 |
Other antiretrovirals |
|
|
Cabotegravir (Vocabria®)
|
Formulary
|
In line with NICE
|
NICE TA757: Cabotegravir with rilpivirine for treating HIV-1
|
Elbasvir with grazoprevir (Zepatier®)
|
Formulary
|
|
|
|
Enfuvirtide (Fuzeon®)
|
Formulary
|
|
|
|
Maraviroc
(tablets)
|
Formulary
|
|
|
|
Maraviroc (Celsentri®)
(tablets)
|
Formulary
|
|
|
|
Raltegravir (Isentress ®)
(tablets)
|
Formulary
|
|
|
|
| 05.03.01 |
Pharmacokinetic enhancers of antiretrovirals |
|
|
Cobicistat (Tybost ®)
|
Formulary
|
|
|
|
| 05.03.01 |
Combination Products |
|
|
| 05.03.02 |
Herpesvirus infections |
|
|
Aciclovir lauriad (Sitavig)
|
Formulary
|
|
|
|
| 05.03.02.01 |
Herpes simplex and varicella-zoster infection |
|
|
Famciclovir
(Oral )
|
Second Choice
|
Second line for Shingles
|
|
|
Valaciclovir
(Oral presentations)
|
Second Choice
|
To be used in exceptional cases only
Least cost effective option
Second line for shingles if compliance is a problem
£££££
|
|
|
Aciclovir
(injection)
|
Formulary
|
|
|
|
Aciclovir
(Oral presentations)
|
Formulary
|
Tablets most cost effective choice
Dispersible tablets £
Suspension ££
|
|
|
Inosine Pranobex (Imunovir®)
|
Formulary
|
|
|
|
| 05.03.02.02 |
Cytomegalovirus infection |
|
|
Cidofovir
|
Formulary
|
|
|
|
Foscarnet Sodium
(infusion)
|
Formulary
|
|
|
|
Foscarnet Sodium (Foscavir®)
(infusion)
|
Formulary
|
|
|
|
Ganciclovir
(infusion)
|
Formulary
|
|
|
|
Ganciclovir (Cymevene®)
(infusion)
|
Formulary
|
|
|
|
Letermovir (Prevymis®)
|
Formulary
|
In line with NICE
|
NICE TA591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
|
Valganciclovir
(Oral presentations)
|
Formulary
|
|
|
|
| 05.03.03 |
Viral hepatitis |
|
|
Adefovir Dipivoxil (Hepsera®)
|
Formulary
|
|
NICE CG165: Hepatitis B (chronic) - diagnosis and management
NICE TA96: Adefovir dipivoxil and peginterfeon alfa-2a for the treatment of chronic hepatitis B
|
Entecavir
|
Formulary
|
|
NICE CG165: Hepatitis B (chronic) - diagnosis and management
NICE TA153: Entecavir for the treatment of chronic hepatitis B
|
Entecavir (Baraclude®)
|
Formulary
|
|
NICE CG165: Hepatitis B (chronic) - diagnosis and management
NICE TA153: Entecavir for the treatment of chronic hepatitis B
|
| 05.03.03.01 |
Chronic hepatitis B |
|
|
Tenofovir alafenamide (Vemlidy®)
|
Formulary
|
|
|
|
Tenofovir Disproxil
(Oral presentations)
|
Formulary
|
|
|
|
| 05.03.03.02 |
Chronic hepatitis C |
|
|
Glecaprevir-pibrentasvir (Maviret®)
|
Formulary
|
In line with NICE
|
NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
|
Ledipasvir/sofosbuvir (Harvoni®)
|
Formulary
|
In line with NICE
|
NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
|
Sofosbuvir (Sovaldi®)
|
Formulary
|
|
|
|
Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi®)
|
Formulary
|
In line with NICE
|
NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
|
Sofosbuvir/velpatasvir (Epclusa®)
|
Formulary
|
In line with NICE
|
NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
|
| 05.03.04 |
Influenza |
|
|
Oseltamivir
(Oral presentations)
|
First Choice
|
-For Primary Care- Green only during Flu season and on authorisation by NHS England/Department of Health & Social Care or via commissioned service for out of season supply
|
UKMI Q&A: Oseltamivir or zanamivir – can mothers breastfeed after treatment for influenza?
TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
PHE guidance on use of antiviral agents for the treatment and prophylaxis of seasonal influenza
|
Oseltamivir (Tamiflu®)
(capsules & suspension SF)
|
First Choice
|
-For Primary Care- Green only during Flu season and on authorisation by NHS England/Department of Health & Social Care or via commissioned service for out of season supply
|
UKMI Q&A: Oseltamivir or zanamivir – can mothers breastfeed after treatment for influenza?
TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
PHE guidance on use of antiviral agents for the treatment and prophylaxis of seasonal influenza
|
Zanamivir (Relenza®)
(dry powder for inhalation )
|
Second Choice
|
For Primary Care-Green only during Flu season and on authorisation by NHS England/Department of Health & Social Care or via commissioned service for out of season supply
|
UKM I Q&A: Oseltamivir or zanamivir – can mothers breastfeed after treatment for influenza?
TA 168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
|
Amantadine Hydrochloride
|
Formulary
|
|
|
|
Zanamivir Injection (Dectova ®)
|
Formulary
|
|
|
|
|
|
| 05.03.05 |
Respiratory syncytial virus |
|
|
Palivizumab (Synagis®)
(Injection)
|
Formulary
|
|
|
|
Ribavirin
(Tablet, Capsules & Inhalation)
|
Formulary
|
|
NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
|
| 05.04 |
Antiprotozoal drugs |
|
|
Artemether > Riamet
|
Formulary
|
|
|
|
Artesunate
(Injection)
|
Formulary
|
|
|
|
Atovaquone
|
Formulary
|
|
|
|
Chloroquine
(Tablets)
|
Formulary
|
Green for treatments NHS funded
|
|
|
Diloxanide
|
Formulary
|
|
|
|
Doxycycline (Vibramycin-D®)
|
Formulary
|
|
|
|
Mefloquine
|
Formulary
|
|
|
|
Mefloquine (Lariam®)
(Tablets)
|
Formulary
|
Private prescription in Primary Care
|
|
|
Mepacrine
(tablets)
|
Formulary
|
|
|
|
Metronidazole
(IV/Suppository)
|
Formulary
|
|
|
|
Metronidazole
(Oral presentations)
|
Formulary
|
|
|
|
Metronidazole (Acea ®)
(gel)
|
Formulary
|
For acne rosacea only NOT infected wounds.
|
|
|
Metronidazole (Anabact®)
(Gel)
|
Formulary
|
For wounds, malodorous tumours and skin ulcers.
|
|
|
Metronidazole (Metrogel®)
|
Formulary
|
|
|
|
Metronidazole (Rosiced®)
|
Formulary
|
|
|
|
Metronidazole (Rozex ®)
(gel)
|
Formulary
|
For acne rosacea only NOT infected wounds.
|
|
|
Metronidazole (Zidoval®)
(0.75% vaginal gel)
|
Formulary
|
|
|
|
Paromomycin
(Suspension)
|
Formulary
|
Unlicensed
|
|
|
Pentamidine
|
Formulary
|
|
|
|
Pentamidine > Pentacarina
|
Formulary
|
|
|
|
Proguanil
|
Formulary
|
Private Prescription in Praimary care
|
|
|
Proguanil > Paludrine
|
Formulary
|
Private prescription in Praimary care
|
|
|
Proguanil Hydrochloride with Atovaquone
(tablets)
|
Formulary
|
Private prescription in Primary Care
|
|
|
Pyrimethamine
|
Formulary
|
|
|
|
Pyrimethamine (Daraprim®)
|
Formulary
|
|
|
|
Pyrimethamine with Sulfadoxine (Fansidar®)
|
Formulary
|
|
|
|
Quinine
|
Formulary
|
|
|
|
Quinine Bisulphate
|
Formulary
|
|
|
|
Quinine Dihydrochloride
(Injection)
|
Formulary
|
|
|
|
Doxycycline
|
Formulary
|
|
|
|
| 05.04.01 |
Antimalarials |
|
|
|
|
|
|
| 05.04.01 |
Treatment of malaria |
|
|
|
|
| 05.04.01 |
Artemether with lumefabtrine |
|
|
Artemether with Lumefantrine (Riamet®)
(Tablets)
|
Formulary
|
|
|
|
| 05.04.01 |
Chloroquine |
|
|
| 05.04.01 |
Mefloquine |
|
|
| 05.04.01 |
Primaquine |
|
|
Primaquine
(Tablets)
|
Formulary
|
|
|
|
| 05.04.01 |
Proguanil |
|
|
Proguanil Hydrochloride
|
Formulary
|
Private prescription in Primary Care
|
|
|
| 05.04.01 |
Pyrimethamine |
|
|
| 05.04.01 |
Quinine |
|
|
Quinine Sulphate
(Tablets)
|
Formulary
|
|
|
|
| 05.04.01 |
Tetracyclines |
|
|
| 05.04.02 |
Amoebicides |
|
|
| 05.04.03 |
Trichomonacides |
|
|
| 05.04.04 |
Antigiardial drugs |
|
|
Nitazoxanide
(tablets & suspension)
|
Formulary
|
Not in BNF (Phase 2 trials)
|
|
|
| 05.04.05 |
Leishmaniacides |
|
|
| 05.04.06 |
Trypanocides |
|
|
| 05.04.07 |
Drugs for toxoplasmosis |
|
|
Sulfadiazine
|
Formulary
|
|
|
|
| 05.04.08 |
Drugs for pneumocystis pneumonia |
|
|
Pentamidine Isetionate (Pantacarinat®)
|
Formulary
|
|
|
|
| 05.05 |
Anthelmintics |
|
|
Albendazole
(chewable tablets)
|
Formulary
|
Unlicensed
|
|
|
Diethylcarbamazine
|
Formulary
|
|
|
|
Ivermectin
|
Formulary
|
Unlicensed, for crusted scabies, on specialist advice
|
|
|
Ivermectin > Soolantra
|
Formulary
|
|
|
|
Levamisole
|
Formulary
|
Unlicensed
|
|
|
Levamisole > Ergamisol
|
Formulary
|
|
|
|
Mebendazole
|
Formulary
|
Also available to buy OTC
|
UKMI Q&A: Threadworm treatment druing pregnancy
|
Mebendazole > Vermox
|
Formulary
|
|
|
|
Niclosamide
|
Formulary
|
|
|
|
Praziquantel
(Tablets)
|
Formulary
|
Unlicensed
On Specialist advice only
|
|
|
Praziquantel > Cysticide
|
Formulary
|
|
|
|
Sodium Stibogluconate (Pentostam®)
(Injectable)
|
Formulary
|
|
|
|
Spiramycin
|
Formulary
|
Unlicensed
|
|
|
Sulfadiazine
(tablets)
|
Formulary
|
|
Potential Primary Care Medication Error: Confusing sulfasalazine and sulfadiazine (The Royal Wolverhampton NHS Trust, 17/03/2021)
|
Tiabendazole 500mg tabs
|
Formulary
|
|
|
|
Tinidazole
(tablets)
|
Formulary
|
|
|
|
| 05.05.01 |
Drugs for threadworms |
|
|
| 05.05.02 |
Ascaricides |
|
|
| 05.05.03 |
Drugs for tapeworm infections |
|
|
| 05.05.03 |
Taenicides |
|
|
| 05.05.03 |
Hydatid disease |
|
|
| 05.05.04 |
Drugs for hookworms |
|
|
| 05.05.05 |
Schistosomicides |
|
|
| 05.05.06 |
Filaricides |
|
|
| 05.05.07 |
Drugs for cutaneous larva migrans |
|
|
| 05.05.08 |
Drugs for strongyloidiasis |
|
|
| .... |
| Non Formulary Items |
Abacavir (Ziagen®)
|
Non Formulary
|
|
|
|
Abacavir and Lamivudine (Kivexa®)
(tablets)
|
Non Formulary
|
|
|
|
Abacavir and Lamivudine and Zidovudine (Trizivir®)
|
Non Formulary
|
|
|
|
Amantadine Hydrochloride (Symmetrel®)
|
Non Formulary
|
|
|
|
Amikacin (Arikayce liposomal 590mg nebuliser dispersion)
|
Non Formulary
|
|
|
|
Ampicillin
|
Non Formulary
|
|
|
|
Ampicillin
|
Non Formulary
|
|
|
|
Amprenavir (Agenerase®)
|
Non Formulary
|
|
|
|
Artemether with lumefantrine (Riamet®)
|
Non Formulary
|
|
|
|
Artenimol > Eurartesim
|
Non Formulary
|
|
|
|
Artenimol With Piperaquine Phosphate
|
Non Formulary
|
|
|
|
Atovaquone > Malarone
|
Non Formulary
|
|
|
|
Atovaquone With Proguanil Hydrochloride
|
Non Formulary
|
|
|
|
Azithromycin (Zedbac)
|
Non Formulary
|
|
|
|
Azithromycin (Zithromax)
|
Non Formulary
|
|
|
|
Aztreonam nebuliser solution (Cayston®)
|
Non Formulary
|
|
|
|
Cefaclor
|
Non Formulary
|
|
|
|
Cefaclor (Distaclor®)
|
Non Formulary
|
|
|
|
Cefaclor (Distaclor® MR)
|
Non Formulary
|
|
|
|
Cefadroxil
|
Non Formulary
|
|
|
|
Cefoxitin
|
Non Formulary
|
|
|
|
Cefoxitin (Renoxitin®)
|
Non Formulary
|
|
|
|
Cefpodoxime
|
Non Formulary
|
|
|
|
Cefradine
|
Non Formulary
|
|
|
|
Ceftaroline (Zinforo®)
|
Non Formulary
|
|
|
|
Cefuroxime Axetil
|
Non Formulary
|
|
|
|
Chloroquine (Avloclor®)
|
Non Formulary
|
|
|
|
Chloroquine (Malarivon®)
|
Non Formulary
|
|
|
|
Chloroquine (Nivaquine®)
|
Non Formulary
|
|
|
|
Chloroquine (Proguanil®)
|
Non Formulary
|
|
|
|
Ciprofloxacin (Ciproxin®)
|
Non Formulary
|
|
|
|
Clarithromycin (Klaricid®)
|
Non Formulary
|
|
|
|
Clarithromycin (Klaricid® XL)
|
Non Formulary
|
|
|
|
Clarithromycin (Xetinin XL®)
|
Non Formulary
|
|
|
|
Clindamycin (Dalacin C®)
|
Non Formulary
|
|
|
|
Clindamycin 300mg Capsules
|
Non Formulary
|
|
|
|
Co-Amoxiclav (Augmentin®)
|
Non Formulary
|
|
|
|
Co-Amoxiclav (Augmentin-Duo®)
|
Non Formulary
|
|
|
|
Co-Fluampicil
|
Non Formulary
|
|
|
|
Collatamp EG Sponge
|
Non Formulary
|
|
|
|
Daptomycin (Cubicin®)
|
Non Formulary
|
|
|
|
Darunavir (Prezista®)
(tablets)
|
Non Formulary
|
|
|
|
Delafloxacin (Quofenix®)
|
Non Formulary
|
|
|
|
Didanosine (Videx®)
(capsules)
|
Non Formulary
|
|
|
|
Doxycycline (Efracea® MR)
|
Non Formulary
|
|
|
|
Doxycycline (Periostat®)
|
Non Formulary
|
|
|
|
Efavirenz
(Tablets)
|
Non Formulary
|
|
|
|
Efavirenz with emtricitabine and tenofovir disoproxil (Atripla® )
|
Non Formulary
|
|
|
|
Emtricitabine with tenofovir disoproxil (Ictastan®)
|
Non Formulary
|
|
|
|
Emtricitabine with tenofovir disoproxil (Truvada®)
|
Non Formulary
|
|
|
|
Ertapenem (Invanz®)
(injection)
|
Non Formulary
|
|
|
|
Erythromycin (Erythrocin®)
|
Non Formulary
|
|
|
|
Erythromycin (Erythroped®)
|
Non Formulary
|
|
|
|
Fidaxomicin (Dificlir®)
|
Non Formulary
|
|
|
|
Fluconazole
|
Non Formulary
|
Capsules
Suspension - Only for patients with swallowing difficulties |
|
|
Fosfomycin (Fomicyt ®)
|
Non Formulary
|
|
|
|
Fosfomycin 3g granules sachets (Alexi ®)
|
Non Formulary
|
|
|
|
Fosfomycin 3g granules sachets (Monuril ®)
|
Non Formulary
|
|
|
|
Fostemsavir (Rukobia®)
|
Non Formulary
|
|
|
|
Griseofulvin (Fulsolvin®)
|
Non Formulary
|
|
|
|
Indinavir (Crixivan®)
|
Non Formulary
|
|
|
|
Levofloxacin 240mg nebuliser solution ampoules (Quinsair®)
|
Non Formulary
|
|
|
|
Linezolid (Zyvox®)
|
Non Formulary
|
|
|
|
Lymecycline (Tetralysal 300 capsules®)
|
Non Formulary
|
|
|
|
Metronidazole (Metrosa®)
|
Non Formulary
|
|
|
|
Minocycline
|
Non Formulary
|
|
|
|
Minocycline (Acnamino® MR)
|
Non Formulary
|
|
|
|
Minocycline (Minocin® MR)
|
Non Formulary
|
|
|
|
Nelfinavir
|
Non Formulary
|
|
|
|
Neomycin sulphate
(tablets)
|
Non Formulary
|
For hospital use only or advice from Specialist/Microbiologist |
|
|
Nitrofurantoin (Macrobid®)
|
Non Formulary
|
|
|
|
Oritavancin
|
Non Formulary
|
|
|
|
Piperazine
|
Non Formulary
|
|
|
|
Pivmecillinam (Selexid®)
|
Non Formulary
|
|
|
|
Proguanil Hydrochloride with Atovaquone (Malarone®Paediatric)
|
Non Formulary
|
Private prescription in Primary Care |
|
|
Pyrimethamine and Dapsone
|
Non Formulary
|
|
|
|
Quinupristin and dalfopristin (Synercid®)
(injection)
|
Non Formulary
|
|
|
|
Ritonavir (Norvir®)
(tablets & SF solution)
|
Non Formulary
|
|
|
|
Saquinavir (Invirase®)
(tablets)
|
Non Formulary
|
|
|
|
Stavudine
(capsules)
|
Non Formulary
|
|
|
|
Telithromycin (Ketek®)
|
Non Formulary
|
|
|
|
Tenofovir Disproxil (Viread®)
|
Non Formulary
|
|
|
|
Tenofovir Disproxil (Viread®)
(tablets)
|
Non Formulary
|
|
NICE CG165: Hepatitis B (chronic) - diagnosis and management
NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
|
test Chronic hepatitis C
|
Non Formulary
|
|
|
|
Tinidazole
|
Non Formulary
|
|
|
|
Tinidazole (Fasigyn®)
|
Non Formulary
|
|
|
|
Tipranavir (Aptivus®)
|
Non Formulary
|
|
|
|
Zidovudine (Retrovir®)
(capsules )
|
Non Formulary
|
|
|
|
Zidovudine and Lamivudine (Combivir®)
(tablets)
|
Non Formulary
|
|
|
|
| |
Key |
|
Restricted Drug |
|
Unlicensed |
|
|
Link to adult BNF
|
|
|
Link to children's BNF
|
|
|
Link to SPCs
|
|
Cytotoxic Drug |
|
Controlled Drug |
|
|
High Cost Medicine |
|
Cancer Drugs Fund |
|
NHS England |
|
Homecare |
|
ICB |
|
Low carbon footprint |
|
Medium carbon footprint |
|
High carbon footprint |
|
| Status |
Description |
|
Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications |
|
Amber Specialist Initiation: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate. This may be supported by a RICaD, annotated within the formulary entry. |
|
Amber Shared Care: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing, in accordance with an ESCA, annotated within the formulary entry. |
|
Amber Specialist Recommendation: Initiation and maintenance of prescribing in Primary Care following recommendation from a specialist. |
|
Medicines for initiation and maintenance prescribing by Specialists (hospital or GPs with Special Interest) only |
|
Positive NICE TA and /or awaiting local clarification on place in therapy; Please contact your Medicines Optimisation team for more information. |
|
Non-formulary Medicines which APC/Trust DTC has actively reviewed and do not recommend for use. |
|
Check Notes as varies across the area |
|
|
|
