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 Formulary Chapter 2: Cardiovascular system - Full Chapter
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02.12  Expand sub section  Lipid-regulating drugs
AlirocumabRestricted Item  (Praluent®)
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Formulary
Red
In line with NICE. 
Link  NICE TA393: Alirocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia
 
Bempedoic acid
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Formulary
Red
 
 
EvolocumabRestricted Item  (Repatha®)
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Formulary
Red
In line with NICE. 
Link  NICE TA394: Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia
 
InclisiranBlack Triangle (Leqvio® )
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Formulary
Green

Inclisiran is covered by NICE TA 733.

 
Link  Inclisiran dosing and administration guide
Link  BCWB ICS CVD CLN Position Statement: Inclisiran (Leqvio). Approved 09/02/2022
Link  Medicines Optimisation Pack for INCLISIRAN
Link  Letter to accompany Inclisiran Medicines Optimisation pack October 2021
Link  NICE TA733: Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemia
Link  Procurement guide Inclisiran
Link  RCGP- BMA (December 2021): Information on the proposals for the prescription of inclisiran in primary care settings
 
Volanesorsen
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Formulary
Red
 
 
02.12  Expand sub section  Bile acid sequestrants
Colesevelam (Cholestagel®)
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Formulary
Amber Initiation
 
 
Colestipol  (Colestid®)
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Formulary
Amber Recommended

 

 
 
Colestyramine
(Sachets)
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Formulary
Amber Recommended
 
 
02.12  Expand sub section  Ezetimibe
Ezetimibe (Ezetrol®)
(Tablets)
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Formulary
Green

In line with NICE.

 
Link  NICE TA385: Ezetimibe for treating primary heterozygous-familial and non-familial hypercholesterolaemia
Link  NICE TA694: Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia
 
02.12  Expand sub section  Fibrates
Bezafibrate
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Formulary
Green

Immediate release formulation

Modified release formulation

 
 
Fenofibrate
(Tablets, Capsules)
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Formulary
Green
 
 
02.12  Expand sub section  Statins to top
Atorvastatin
(Tablets)
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Formulary
Green
 
Link  CG181: Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
 
Pravastatin
(Tablets)
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Formulary
Green
 
Link  CG181: Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
 
Rosuvastatin
(Tablets)
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Formulary
Green

Restricted to patients unable to tolerate other low cost generic statins.

 
Link  CG181: Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
 
Simvastatin
(Tablets)
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Formulary
Green
 
Link  CG181:Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
 
02.12  Expand sub section  Nicotinic acid group
02.12  Expand sub section  Omega-3 fatty acid compounds
Icosapent ethyl
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Formulary
Green
 
Link  NICE TA805 :Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglycerides
 
02.12  Expand sub section  PCSK9 inhibitors
02.12  Expand sub section  Other lipid modifying agents
Bempedoic acid with ezetimibe (Nustendi®)
(Tablets)
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Formulary
Green

In line with NICE

 

 
Link  NICE TA694: Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemia
 
 ....
 Non Formulary Items
Acipimox

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Non Formulary
Black
Acipimox  (Olbetam®)

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Non Formulary
Ciprofibrate

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Non Formulary
Black
Colestyramine  (Questran®, Questran® Light)

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Non Formulary
Fluvastatin
(Capsules)

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Non Formulary
Black
Link  CG181: Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
Fluvastatin  (Lescol® XL)

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Non Formulary
Black
Fluvastatin m/r

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Non Formulary
Black
Gemfibrozil

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Non Formulary
Black
Gemifibrozil

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Non Formulary
Gemifibrozil  (Lopid®)

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Non Formulary
Lomitapide Black Triangle  (Lojuxta®)

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Non Formulary
Black
Nicotinic Acid

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Non Formulary
Black
Nicotinic acid/ laropiprant  (Tredaptive ®)

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Non Formulary
Black
Omega-3-Acid Ethyl Esters  (Omacor®)
(Capsules)

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Non Formulary
Black
Link  Patient Information: Changes to omega-3 fatty acids prescribing
Link  UKMI Q&A: Review of evidence dor dyslexia
Omega-3-Marine Triglycerides  (Maxepa)
(Capsules)

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Non Formulary
Black
Link  Patient Information: Changes to omega-3 fatty acids prescribing
Pravastatin Sodium  (Lipostat®)

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Non Formulary
Simvastatin  (Zocor®)

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Non Formulary
Simvastatin and Ezetimibe  (Inegy®)

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Non Formulary
Black
Simvastatin with fenofibrate

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Non Formulary
Black
  
Key
Restricted Drug Restricted Drug
Unlicensed Drug Unlicensed
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
ICB
ICB
Green Low Carbon

Low carbon footprint

Amber Medium Carbon

Medium carbon footprint

Red High carbon footprint

High carbon footprint

Status Description

Green

Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications  

Amber Initiation

Amber Specialist Initiation: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate. This may be supported by a RICaD, annotated within the formulary entry.  

Amber SC

Amber Shared Care: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing, in accordance with an ESCA, annotated within the formulary entry.  

Amber Recommended

Amber Specialist Recommendation: Initiation and maintenance of prescribing in Primary Care following recommendation from a specialist.  

Red

Medicines for initiation and maintenance prescribing by Specialists (hospital or GPs with Special Interest) only  

Grey

Positive NICE TA and /or awaiting local clarification on place in therapy; Please contact your Medicines Optimisation team for more information.  

Black

Non-formulary Medicines which APC/Trust DTC has actively reviewed and do not recommend for use.  

Multiple

Check Notes as varies across the area  

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